Quick disclosure first. I take Zepbound at 12.5mg, prescribed by my doctor and covered by insurance. If the coverage went away tomorrow I’d be on LillyDirect cash-pay before the end of the week. That’s where I’m coming from. I admit I am fascinated by the rise of peptides. It’s as much a business story as
Updated September 26, 2026 with a note that Lilly is testing brenipatide as a weekly shot, not a monthly one. Updated September 9, 2026: added a section below on the smoking-relapse-prevention trial and a newly registered COPD trial. I quit drinking after getting headaches, looking at the evidence and deciding it wasn’t worth it. Most
I paid for two scans six months apart while losing 35 pounds on Zepbound, and the number I bragged about here is the one I got wrong. An earlier version of this post had a parenthesis in it that I am now embarrassed by. I wrote that my second DEXA scan showed 9.6 pounds of
This will kick the GLP-1RA revolution in a new gear. it’s already one of the most common drug classes in the US and not having to inject and falling prices (see Novo Nodirsk’s subscription model) will help with access. I think being able to use a pill instead of an injection will be a huge
November 2024 Once my PCP prescribed Zepbound, the challenge began: convincing insurance to pay for it or getting it filled while paying myself. For background, I work for a large company and think I have pretty decent health insurance (administered by United Healthcare). My pharmacy called me to tell me that the insurance rejected the
The New York Times published a good article about “Why Obesity kills American Men”. I certainly fall into that category. I got use to my doctor telling me “you should lose some weight” every year. Then I started avoided annual physicals because I didn’t want to hear it. However, when I finally got a
I aimed at 200 grams a day, averaged 164, and the DEXA still came back with 9.6 pounds more lean mass than I started with. I published the first version of this post in August 2025 with three different protein targets in it. The body text said 1 gram per pound of target weight, which
