Foundayo vs the Wegovy Pill: The First Oral GLP-1s, Compared
The first two oral GLP-1 pills are here. A head-to-head on the real weight-loss numbers, daily routine, manufacturing, cost, and who each one actually fits.
Medicine 3.0
Medicine 3.0
A Single Shot That Cuts Your LDL by 62 Percent. The Catch: It Edits Your DNA.
Eli Lilly’s VERVE-102 gene-editing therapy cut LDL by 62 percent at the highest dose in Phase 1, with no treatment-related serious adverse events. It edits a single DNA letter in the PCSK9 gene of liver cells. The effect appears permanent. The trade-off is that you cannot undo it.
Medicine 3.0
I’m Still on 5 Grams of Creatine. A New Depression Paper Has Me Watching the Dose Wars With Some Skepticism.
A new Cell Metabolism paper connects creatine to depression through the gut microbiome. The effect is real, but it shows up only in clinically diagnosed depressed patients who are already on antidepressants. The dose-creep crowd is about to ignore that distinction.
Medicine 3.0
Brenipatide vs Tirzepatide: What the Comparison Actually Looks Like in 2026
People on tirzepatide ask if brenipatide is the upgrade. People reading about brenipatide ask how it compares to the drug everyone is already on. Same class. Very different jobs. A head-to-head comparison.
Medicine 3.0
I Keep Hearing About NAD+. Here Is What the New Research Actually Says.
Huberman talks about it, Bryan Johnson takes it, Goop sells it, Walgreens stocks it. After months of hearing the NAD+ pitch repeated, I still could not tell whether it was a breakthrough or snake oil. Two new human studies gave me the clearest answer I have read.
Medicine 3.0
I Got Shingrix to Avoid My Wife’s Misery. Then the Dementia and Cardiovascular Data Showed Up.
I got Shingrix at 52 because my wife had shingles and the pain was the worst she has ever felt. In the eighteen months since, the evidence that the vaccine also lowers dementia and cardiovascular risk has piled up faster than almost any other intervention in adult medicine.
Medicine 3.0
Kyle Busch Died of Sepsis. Most of Us Don’t Know What That Actually Means.
NASCAR champion Kyle Busch died after pneumonia progressed to sepsis. Most of us, including me, misunderstand what sepsis actually is. A clear explainer of the body’s dysregulated response, the TIME warning signs, and what to do.
Fitness Journey, Medicine 3.0
I Lost 170 Pounds. Everyone Asked If I Was Doing Keto. I Wasn’t.
I’m 170 pounds down on tirzepatide. The most-asked question I get now is ‘is it keto?’ It wasn’t. A 50-something dad untangles what keto, carnivore, low-carb, Mediterranean, and DASH actually are — and what the evidence says about each.
Medicine 3.0
My Wife Just Bought Calcium Chews. A New BMJ Paper Says I’d Skip Them.
My wife bought a pink tub of Viactiv calcium chews because that’s what you do for your bones. Then a new BMJ meta-analysis of 69 trials and 153,902 patients found calcium and vitamin D supplements don’t prevent fractures. What 50-something dads (and wives) should actually do.
Medicine 3.0
The Functional Medicine Empire: What It Actually Is, What It Sells, and Where It Breaks Down
I have been trying to figure out what “functional health” actually means for about a month, and the first thing I noticed is that the people selling it cannot agree on the term. The same business model gets called “functional medicine,” “functional health,” “root-cause medicine,” “integrative medicine,” and “personalized medicine” by practitioners who all want