Rowing Machine or Bike for a Bad Knee? I Own Both. Start With the Bike.
Both machines live in my garage. With a bone-on-bone knee, the bike gets most of the work, and the knee-loading studies support that order.
cardio, Home Gym
Cholesterol, Heart & Bloodwork, Preventive Health
The First Big Lp(a) Drug Trial Missed Its Main Goal. It Put LDL Back at the Top of My List.
Pelacarsen missed its primary endpoint in the Lp(a)HORIZON trial. Here’s what’s actually known, what two doctors think happened, and why I’m putting my own effort back into LDL and ApoB instead of waiting on an Lp(a) drug.
GLP-1, Preventive Health
Retatrutide Cost: No Price Yet, and My Estimate Is $450 to $650 a Month
I paid Lilly’s self-pay price for Zepbound for months, and retatrutide has no announced price yet, so here is what Lilly’s own price ladders imply.
GLP-1, Preventive Health
Does CagriSema Have a Brand Name Yet?
CagriSema has no announced brand name as of September 4, 2026. Novo Nordisk owns eleven invented names it could use, and it bought the matching web address for only six of them.
GLP-1, Healthcare
Is CagriSema Covered by Medicare? Not Yet, and Here Is What Would Change That
CagriSema is not approved, so Medicare does not cover it. Here are the three routes after the FDA decides: the $50 Medicare GLP-1 Bridge, regular Part D, or the CagriSema cost without insurance.
GLP-1, Healthcare
CagriSema vs Zepbound: The New Combo Couldn’t Prove It Matches the Drug I’m On
Novo’s own head-to-head could not show CagriSema was as good as tirzepatide. I take Zepbound myself, and I go through both sets of numbers, plus the three brand names Novo has registered, including Wegovamy.
GLP-1, Preventive Health
Does Retatrutide Have a Brand Name Yet?
Retatrutide still has no brand name. But Lilly filed 20 new trademarks in a month and 19 are built on reta, from VYNRETA to YEZRETA. Here is the whole list, which domains Lilly quietly bought first, and what happened the last time it did this.
GLP-1, Preventive Health
Retatrutide vs Zepbound: Is Lilly’s Next Weight-Loss Shot Worth Waiting For?
Retatrutide beat Zepbound’s numbers in its own trials, and it did not need its top dose to do it. I take Zepbound, I lost about 170 pounds on it, and I am staying put.
Medicine 3.0, Preventive Health
A Zero Calcium Score Isn’t the Whole Story. But the $2,000 Scan Isn’t Either.
My coronary calcium score is zero. What a zero doesn’t rule out, what a new NEJM study found about plaque without calcium, and whether the $2,000 AI heart scan (Cleerly or HeartFlow) is worth it at 53.
Cholesterol, Heart & Bloodwork, Medicine 3.0, Preventive Health
Heart Attacks Were 43% Lower With a Statin in Adults Over 70. Cardiovascular Deaths Were Not.
I do not take a statin. I got my ApoB to 59 with about 170 pounds of weight loss and a generic ezetimibe that runs me twenty dollars a month, so when a big statin trial reads out I have nothing invested in the answer. I have also written here about why most of the