The FDA approved Lipfendra (enlicitide), the first oral PCSK9 inhibitor. What it costs, how the pill compares to the shots, and who actually needs it.
The “five times the risk” number is real. The useful lesson for a fifty-year-old is smaller, less sexy, and more actionable. I have read the claim that VO2 max is the single best predictor of how long you will live so many times that I had stopped seeing it. It is everywhere in the longevity
The most influential cholesterol educator alive can’t tolerate statins or ezetimibe. When he needed the expensive PCSK9 drug, his insurer said his numbers were too good to cover.
Eli Lilly’s VERVE-102 gene-editing therapy cut LDL by 62 percent at the highest dose in Phase 1, with no treatment-related serious adverse events. It edits a single DNA letter in the PCSK9 gene of liver cells. The effect appears permanent. The trade-off is that you cannot undo it.
My wife bought a pink tub of Viactiv calcium chews because that’s what you do for your bones. Then a new BMJ meta-analysis of 69 trials and 153,902 patients found calcium and vitamin D supplements don’t prevent fractures. What 50-something dads (and wives) should actually do.
Your cholesterol panel at 50, decoded. The six numbers, the new 2026 guideline targets, the coronary calcium scan, and what the drugs actually do.
In May 2026, three major papers landed on Lp(a) — the genetic cholesterol marker that 1 in 5 adults carry at risk levels and almost nobody gets tested for. Here’s what the new evidence says, what to do if your number is high, and the aspirin advice you should stop following.
I knew statins worked. I did not know how strange the origin story was. How statins started with mold Get the next one in your inbox I write about longevity, training, and preventive health weekly — without the guru worship. Free, no spam, unsubscribe whenever. The first statin came from Akira Endo, a Japanese biochemist
I went to the DMV last week Totally routine paperwork to get the RealID star and that brutally honest camera they use that somehow makes everyone look slightly guilty. Five years ago, I sat in that same spot for my last license photo. When the new license cane in the mail today, I pulled out
I spent most of my life thinking heart disease was something that happened to “other guys.” I don’t have a family history of heart problems but obviously occasionally heard of cases. The older guy at the office. The guy who never exercised. The friend who lived on pizza and stress. Then I started looking at
