I inject myself a few times a week now, GLP-1 and TRT, and barely notice. The needle, not the drug, is the real barrier in modern health, and it is starting to fall.
The first two oral GLP-1 pills are here. A head-to-head on the real weight-loss numbers, daily routine, manufacturing, cost, and who each one actually fits.
Eli Lilly’s VERVE-102 gene-editing therapy cut LDL by 62 percent at the highest dose in Phase 1, with no treatment-related serious adverse events. It edits a single DNA letter in the PCSK9 gene of liver cells. The effect appears permanent. The trade-off is that you cannot undo it.
A new Cell Metabolism paper connects creatine to depression through the gut microbiome. The effect is real, but it shows up only in clinically diagnosed depressed patients who are already on antidepressants. The dose-creep crowd is about to ignore that distinction.
People on tirzepatide ask if brenipatide is the upgrade. People reading about brenipatide ask how it compares to the drug everyone is already on. Same class. Very different jobs. A head-to-head comparison.
Huberman talks about it, Bryan Johnson takes it, Goop sells it, Walgreens stocks it. After months of hearing the NAD+ pitch repeated, I still could not tell whether it was a breakthrough or snake oil. Two new human studies gave me the clearest answer I have read.
I got Shingrix at 52 because my wife had shingles and the pain was the worst she has ever felt. In the eighteen months since, the evidence that the vaccine also lowers dementia and cardiovascular risk has piled up faster than almost any other intervention in adult medicine.
NASCAR champion Kyle Busch died after pneumonia progressed to sepsis. Most of us, including me, misunderstand what sepsis actually is. A clear explainer of the body’s dysregulated response, the TIME warning signs, and what to do.
I’m 170 pounds down on tirzepatide. The most-asked question I get now is ‘is it keto?’ It wasn’t. A 50-something dad untangles what keto, carnivore, low-carb, Mediterranean, and DASH actually are — and what the evidence says about each.
My wife bought a pink tub of Viactiv calcium chews because that’s what you do for your bones. Then a new BMJ meta-analysis of 69 trials and 153,902 patients found calcium and vitamin D supplements don’t prevent fractures. What 50-something dads (and wives) should actually do.
