A new Cell Metabolism paper connects creatine to depression through the gut microbiome. The effect is real, but it shows up only in clinically diagnosed depressed patients who are already on antidepressants. The dose-creep crowd is about to ignore that distinction.
Huberman talks about it, Bryan Johnson takes it, Goop sells it, Walgreens stocks it. After months of hearing the NAD+ pitch repeated, I still could not tell whether it was a breakthrough or snake oil. Two new human studies gave me the clearest answer I have read.
My wife bought a pink tub of Viactiv calcium chews because that’s what you do for your bones. Then a new BMJ meta-analysis of 69 trials and 153,902 patients found calcium and vitamin D supplements don’t prevent fractures. What 50-something dads (and wives) should actually do.
I have been trying to figure out what “functional health” actually means for about a month, and the first thing I noticed is that the people selling it cannot agree on the term. The same business model gets called “functional medicine,” “functional health,” “root-cause medicine,” “integrative medicine,” and “personalized medicine” by practitioners who all want
I really thought it was well known that Creatine does NOT cause kidney disease but merely messes with some of the more simplistic blood markers (creatinine) used to diagnose kidney disease (see Vega et al. 2019 or Longobardi et al. 2023) Certainly this is well known in longevity/biohacking/body building circles. However, even my PCP advised
