Author name: Gunnar Evermann

Gunnar Evermann lost about 170 pounds, trains in a garage gym, and writes DadStrengthDaily from personal experience, citing primary sources where he can. He also moderates r/ProactiveHealth. He is not a doctor, and nothing here is medical advice. More on the About page and in the Editorial Standards.

Bar chart of every Phase 2 and Phase 3 brenipatide trial by listed enrollment, showing four Phase 3 trials in alcohol use disorder and major depression above a block of Phase 2 trials that includes opioid use disorder and smoking relapse.
GLP-1, Preventive Health

Lilly Accelerates Its Brenipatide Trials: Betting Millions on the First GLP-1 for Alcohol and Depression

The brenipatide Phase 3 program is Lilly’s bet that it can reach an alcohol and depression label before anyone else, and it pulls a possible approval years closer. Key Points Lilly sent brenipatide, an experimental GIP/GLP-1 drug, straight from Phase 1 into Phase 3 for alcohol use disorder and major depression, skipping the mid-stage trial

Timeline of all thirteen registered brenipatide clinical trials showing when each finishes collecting its main results, from smoking relapse and a Phase 1 obesity study in February 2027 through a second major depression trial in December 2028. None has posted results on ClinicalTrials.gov.
GLP-1

Brenipatide Side Effects: What’s Known and What Isn’t

Updated September 26, 2026 with Lilly’s first Phase 1 safety data and a note that the drug is dosed weekly, not monthly. Brenipatide side effects: thirteen registered trials, ten conditions, and not one has reported. Here is what is actually known. I take tirzepatide every Friday, so I know exactly what a GLP-1 does to

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